pentobarbital will lower the level or result of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Solid or moderate CYP3A4 inducers may perhaps improve amount of diazepam elimination; hence, efficacy of diazepam could possibly be reduced.
pentobarbital will reduce the level or influence of meloxicam by influencing hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Not known.
Keep track of Carefully (one)pentobarbital will reduce the level or impact of levamlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the extent or effect of alprazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lessen the level or impact of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
pentobarbital will decrease the extent or result of temsirolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will decrease the extent or impact of oxybutynin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.
pentobarbital will reduce the extent or impact of nelfinavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
To reduce the possibility of overdosage or the development of dependence, Restrict the prescribing and dispensing of sedative-hypnotic barbiturates, to the amount expected for your interval right until the following appointment
pentobarbital will lessen the level or impact of diclofenac by impacting hepatic enzyme CYP2C9/10 metabolism. Small/Importance Unidentified.
Check Intently (1)pentobarbital will minimize the level or impact of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to some lower in fentanyl plasma concentrations, insufficient efficacy or, possibly, development of the withdrawal syndrome inside a patient who has developed physical dependence to fentanyl. After halting a CYP3A4 inducer, given that the effects of the inducer decline, the fentanyl plasma concentration will boost which could improve or extend each the therapeutic and adverse effects.
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pentobarbital will lower the extent or impact of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Contraindicated (one)pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration with powerful CYP3A4 inducers; these website drugs lessen publicity to vandetanib by up to 40%.